Intravenous acetylcysteine versus oral and intravenous acetylcysteine: Does a combination therapy decrease side effects of acetylcysteine?
نویسندگان
چکیده
منابع مشابه
Oral or intravenous N-acetylcysteine for acetaminophen poisoning?
Acetaminophen (paracetamol, N-acetyl-p-aminophenol) is an effective, mild analgesic, antipyretic agent and is probably the most widely used of all drugs in the world. It does not share the formidable prostaglandin-dependent toxicity of aspirin and other conventional nonsteroidal anti-inflammatory agents, and when used properly, it has an excellent safety record. In many countries, it is fashion...
متن کاملOral and Intravenous Acetylcysteine for Treatment of Acetaminophen Toxicity: A Systematic Review and Meta-analysis
INTRODUCTION There are few reports summarizing the effectiveness of oral and intravenous (IV) acetylcysteine. We determined the proportion of acetaminophen poisoned patients who develop hepatotoxicity (serum transaminase > 1000 IU/L) when treated with oral and IV acetylcysteine. METHODS Studies were double abstracted by trained researchers. We determined the proportions of patients who develo...
متن کاملFatal myocardial infarction associated with intravenous N-acetylcysteine error
BACKGROUND N-acetylcysteine is used to treat acetaminophen toxicity and is available in both intravenous and oral formulations. Our report describes a patient treated with intravenous N-acetylcysteine for acetaminophen toxicity who died after an anaphylactoid reaction following initiation of the infusion. OBJECTIVE Clinicians should be aware of potential complications when deciding on which f...
متن کاملReduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trial
BACKGROUND Paracetamol poisoning is common worldwide. It is treated with intravenous acetylcysteine, but the standard regimen is complex and associated with frequent adverse effects related to concentration, which can cause treatment interruption. We aimed to ascertain whether adverse effects could be reduced with either a shorter modified acetylcysteine schedule, antiemetic pretreatment, or bo...
متن کاملAcetaminophen overdose and N-acetylcysteine therapy.
Dear Editor, I read with interest the case report by Sule et al,1 published in the February 2006 issue of the journal. They reported a case of massive ingestion of paracetamol, successfully managed by a 3-day infusion of N-acetylcysteine. They concluded that a modified 3-day regime is safe and efficacious. Prolonged infusion of N-acetylcysteine for treatment of significant acetaminophen overdos...
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ژورنال
عنوان ژورنال: Pakistan Journal of Medical Sciences
سال: 2013
ISSN: 1681-715X
DOI: 10.12669/pjms.291(suppl).3522